Essential Thrombocythaemia

Essential Thrombocythaemia(ET) is a chronic blood disorder in which the bone marrow produces an unusually high number of platelets. Platelets are essential for blood clotting, but excessive production can interfere with normal circulation and increase the risk of blood clots or bleeding. ET is classified as a myeloproliferative neoplasm and commonly develops due to acquired changes in genes such as JAK2, CALR, or MPL.

Some people with ET have no noticeable symptoms and are diagnosed after a routine blood test. When symptoms occur, they may include headaches, dizziness, visual disturbances, tingling or burning sensations in the hands and feet, and unusual tiredness. Blood clots may occasionally lead to serious complications such as stroke, heart attack, or deep vein thrombosis.

Diagnosis generally involves a complete blood count, examination of blood cells, genetic testing, and sometimes a bone marrow examination. Treatment depends on age, symptoms, platelet levels, and the individual's risk of clotting or bleeding. Management may include regular monitoring, low-dose aspirin in selected patients, or medicines that reduce platelet production.

With appropriate monitoring and treatment, many people with Essential Thrombocythaemia can maintain a good quality of life and manage the condition effectively over the long term.