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Essential Thrombocythaemia(ET)
is a chronic blood disorder in which the bone marrow produces an
unusually high number of platelets. Platelets are essential for blood
clotting, but excessive production can interfere with normal circulation
and increase the risk of blood clots or bleeding. ET is classified as a
myeloproliferative neoplasm and commonly develops due to acquired changes in
genes such as JAK2, CALR, or MPL.
Some people with ET have no
noticeable symptoms and are diagnosed after a routine blood test. When symptoms
occur, they may include headaches, dizziness, visual disturbances, tingling
or burning sensations in the hands and feet, and unusual tiredness. Blood
clots may occasionally lead to serious complications such as stroke,
heart attack, or deep vein thrombosis.
Diagnosis generally involves
a complete blood count, examination of blood cells, genetic testing, and
sometimes a bone marrow examination. Treatment depends on age, symptoms,
platelet levels, and the individual's risk of clotting or bleeding. Management
may include regular monitoring, low-dose aspirin in selected patients, or
medicines that reduce platelet production.
With appropriate monitoring and treatment, many people with Essential Thrombocythaemia can maintain a good quality of life and manage the condition effectively over the long term.