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Non-Alcoholic Steatohepatitis (NASH) is an advanced stage of fatty liver disease where the liver contains too much fat and is accompanied by inflammation and destruction of liver cells. NASH occurs in individuals who drink little or no alcohol, unlike liver problems due to too much alcohol. It is often connected with obesity, type 2 diabetes, insulin resistance, elevated cholesterol, and metabolic syndrome.

NASH generally has no symptoms in its early stages and is difficult to identify without medical evaluation. Some people may experience weariness, discomfort in the upper right abdomen, weakness, or unexplained weight loss as the disease advances. Chronic inflammation, if left unchecked, can cause liver scarring (fibrosis) and eventually cirrhosis, liver failure, or liver cancer.

Diagnosis is usually made by blood testing, imaging tests such as ultrasound or MRI, and occasionally a liver biopsy to determine the level of inflammation and damage. No approved drug exists today that entirely treats NASH, but lifestyle changes are still the cornerstone of treatment. Losing weight, exercising regularly, eating a healthy diet, and controlling blood sugar and cholesterol levels can help improve liver health and reduce the advancement of illness. Early diagnosis and action are crucial in preventing long-term problems and preserving liver function.