Amyloidosis

Amyloidosis is a rare and serious disease caused by the abnormal buildup of protein fragments called amyloid in organs and tissues, which disrupts their normal function. This buildup results from proteins that misfold and aggregate into insoluble fibrils, primarily affecting the heart, kidneys, liver, nerves, and digestive system. There are several types of amyloidosis, including AL amyloidosis (caused by abnormal plasma cells producing light chain proteins), ATTR amyloidosis (linked to transthyretin protein mutations or aging), and AA amyloidosis (associated with chronic inflammatory diseases).

Symptoms vary depending on the organs involved, often leading to organ dysfunction or failure. Diagnosis involves tissue biopsy and specialized tests, while treatment focuses on reducing amyloid production and managing organ damage. Early detection and tailored therapies can improve outcomes in this progressive disorder.?