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The rare genetic condition known asfamilial adenomatous polyposis (FAP) causes hundreds to thousands of polyps in the colon and rectal lining. Usually at the age of forty, if left untreated, FAP, caused by mutations in the APC gene, greatly raises the risk of colorectal cancer.
Polyps usually start as benign growths during the teenage years, but over time, the excessive number of these growths almost certainly leads to malignant change. Sometimes polyps also arise in the stomach, small intestine, or other organs, raising the risk of various cancers.
Particularly for those with a family history of FAP, early identification by genetic testing and regular colonoscopy is absolutely crucial. Management plans include frequent surveillance as well as, often, preventive colectomy to lower cancer risk.
Managing this disorder over generations depends critically on supportive care, genetic counselling, and family screening. New developments in chemoprevention and molecular research promise less intrusive future therapy possibilities.