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Platelet Storage Pool Disorders (PSPDs) are a group of rare inherited or, less commonly, acquired platelet function disorders in which platelets lack sufficient storage granules or fail to release their contents properly during clot formation. Platelet granules contain important substances that promote platelet activation, aggregation, and blood clot stabilization. When these granules are deficient or dysfunctional, normal clotting is impaired, increasing the risk of excessive bleeding.

Individuals with Platelet Storage Pool Disorders commonly experience easy bruising, frequent nosebleeds, prolonged bleeding after cuts, heavy menstrual bleeding, gum bleeding, and excessive bleeding following surgery or dental procedures. In severe cases, gastrointestinal or internal bleeding may occur, although life-threatening complications are uncommon. Symptoms vary depending on the type and severity of the disorder.

Diagnosis requires a detailed bleeding history, complete blood count, platelet function studies, electro nmicroscopy to assess platelet granules, and specialized laboratory tests. Genetic testing may help identify inherited forms and confirm the diagnosis in selected patients.

Treatment focuses on preventing and controlling bleeding episodes. Mild cases may only require avoiding medications that impair platelet function, such as aspirin. More significant bleeding may be managed with antifibrinolytic medications, desmopressin (DDAVP), or platelet transfusions before major surgery or during severe bleeding episodes. Regular follow-up with a haematologist helps optimize long-term care and improve quality of life.