Acquired Bleeding Disorders

Acquired bleeding disorders are conditions that develop during a person's lifetime rather than being inherited. These disorders occur when the normal blood clotting process is disrupted by underlying diseases, medications, nutritional deficiencies, or immune system abnormalities. Unlike congenital bleeding disorders, acquired conditions can affect individuals of any age and often improve when the underlying cause is treated.

Common causes include liver disease, kidney failure, vitamin K deficiency, disseminated intravascular coagulation (DIC), autoimmune disorders, certain cancers, and the use of blood-thinning medications such as anticoagulants or antiplatelet drugs. Some people may also develop acquired haemophilia, a rare autoimmune disorder in which the body produces antibodies that attack clotting factors.

Symptoms vary depending on the severity of the condition and may include frequent nosebleeds, easy bruising, prolonged bleeding after injuries or surgery, bleeding gums, blood in urine or stools, heavy menstrual bleeding, and spontaneous internal bleeding in severe cases.

Diagnosis involves a detailed medical history, physical examination, and laboratory tests such as complete blood count (CBC), platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), clotting factor assays, and additional specialised investigations.

Treatment focuses on correcting the underlying cause, replacing deficient clotting factors when necessary, adjusting medications, controlling active bleeding, and preventing future bleeding complications through appropriate medical care and regular monitoring.