Platelet Function Disorders

Platelet function disorders are a group of bleeding conditions in which the number of platelets may be normal, but their ability to form an effective blood clot is impaired. Platelets play a vital role in stopping bleeding by adhering to damaged blood vessels and forming the initial clot. When platelet function is defective, excessive or prolonged bleeding can occur even after minor injuries. These disorders may be inherited, such as Glanzmann thrombasthenia and Bernard-Soulier syndrome, or acquired due to medications, kidney disease, blood cancers, or systemic illnesses.

Common symptoms include frequent nosebleeds, easy bruising, bleeding gums, prolonged bleeding from cuts, excessive menstrual bleeding, and increased bleeding after surgery or dental procedures. In severe cases, gastrointestinal bleeding or excessive blood loss following trauma may occur, requiring urgent medical attention.

Diagnosis involves a detailed medical history, physical examination, complete blood count (CBC), platelet function tests, bleeding time assessment, platelet aggregation studies, and specialised laboratory investigations. Identifying the underlying cause is essential for selecting appropriate treatment.

Management depends on the specific disorder and severity of symptoms. Treatment may include avoiding medications that impair platelet function, antifibrinolytic drugs, desmopressin, platelet transfusions, or treating the underlying medical condition. With early diagnosis, regular monitoring, and specialised haematology care, most individuals can effectively control bleeding episodes and maintain a healthy, active lifestyle.