Autoimmune Haemolytic Anaemia

Autoimmune Haemolytic Anaemia is a rare blood disorder in which the body's immune system mistakenly attacks and destroys its own red blood cells. This premature destruction, known as haemolysis, reduces the number of healthy red blood cells available to carry oxygen throughout the body, leading to anaemia. The condition may develop on its own (primary) or occur alongside other illnesses such as autoimmune diseases, infections, certain cancers, or as a reaction to medications. Autoimmune Haemolytic Anaemia is commonly classified into warm and cold types, depending on the temperature at which the harmful antibodies become active. Symptoms often include fatigue, weakness, pale skin, shortness of breath, rapid heartbeat, dizziness, dark urine, and jaundice.

Diagnosis involves blood tests such as a complete blood count, reticulocyte count, bilirubin levels, lactate dehydrogenase (LDH), haptoglobin, and the direct Coombs (direct antiglobulin) test. Treatment depends on the severity and underlying cause and may include corticosteroids, immunosuppressive medicines, monoclonal antibody therapy, blood transfusions, or splenectomy in selected cases. With early diagnosis, appropriate treatment, and regular medical follow-up, many patients can successfully control the condition and maintain a good quality of life.