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Illustration depicting fatty
deposits narrowing a coronary artery due to atherosclerosis.
Coronary artery disease (CAD), also referred to as coronary heart
disease, occurs when the coronary arteries—which supply the heart with
oxygen and nutrients—become damaged or diseased. The primary underlying
mechanism is atherosclerosis, a process where cholesterol, fats,
and other substances accumulate to form plaque deposits on the inner artery
walls. Over time, these plaques harden or rupture, significantly narrowing the
vessel lumen and obstructing essential blood flow.
Symptoms often manifest as
angina, described as chest pain or pressure, particularly during physical
activity or emotional stress. However, many individuals remain asymptomatic
until the disease advances to critical stages, such as myocardial infarction (heart
attack), where total blockage causes irreversible damage to the heart tissue.
Risk factors for CAD
include high blood pressure, elevated cholesterol levels, smoking,
diabetes, physical inactivity, and a family history of heart disease.
Clinical management typically involves a combination of lifestyle
modifications—such as heart-healthy diets and regular exercise—and
pharmacological interventions, including statins, antiplatelet agents, and
blood pressure medications. In advanced cases, surgical procedures like angioplasty
or coronary artery bypass grafting may be required to restore
adequate perfusion to the myocardium.