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Insulin Resistance Syndrome is a metabolic disorder characterised by the body's cells failing to respond adequately to insulin, a hormone that facilitates glucose entry into cells for energy. Because of this, the pancreas makes more insulin to keep blood sugar levels normal. This compensation may not work over time, which can cause high blood sugar levels, prediabetes, or type 2 diabetes. Insulin resistance is closely linked to being overweight, especially having too much fat around the stomach, not getting enough exercise, eating poorly, being under a lot of stress, and having a family history of the condition. It is also often connected to metabolic syndrome, high blood pressure, excessive cholesterol levels, and fatty liver disease.

People with insulin resistance may not notice any signs at first, but some do get tired, gain weight, feel hungrier, develop dark patches of skin around their neck or underarms (acanthosis nigricans), and have trouble reducing weight. Blood sugar levels, fasting insulin, HbA1c, and a physical exam are all used to make a diagnosis. Early treatment focuses on making adjustments to your daily life, like getting regular exercise, losing weight, eating a balanced diet low in sugar, and learning how to deal with stress. In some circumstances, doctors may suggest drugs to make insulin work better. Timely therapy is vital to lower the chances of developing diabetes, heart disease, and long-term metabolic problems.