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Recurrent Implantation Failure (RIF) is the failure to get pregnant after several transfers of good-quality embryos during assisted reproductive procedures, like in vitro fertilisation. RIF is generally defined as three or more unsuccessful embryo transfer cycles or repeated transfers of high-quality embryos without implantation.
Many things can induce RIF, including problems with the uterus (such as polyps, fibroids, or adhesions), problems with the endometrial receptivity, genetic or chromosomal problems in embryos, hormonal imbalances, and problems with the immune system. Antiphospholipid Syndrome and other autoimmune illnesses might make it harder for an embryo to implant. Additionally, failure may be caused by damaged embryos or sperm DNA fragmentation.

A full evaluation is needed to make a diagnosis. This includes hysteroscopy, endometrial receptivity tests, genetic tests, and immunological tests. Management is personalised and may involve rectification of uterine pathology, implementation of preimplantation genetic testing (PGT), hormonal optimisation, anticoagulant therapy, or immunomodulatory treatments.
Improvements in reproductive medicine have led to better outcomes, but RIF is still a difficult condition that needs a personalised, multidisciplinary strategy to improve implantation success and pregnancy.