Recurrent IVF Failure Due To Genetic Causes

Recurrent in vitro fertilisation (IVF) failure due to genetic factors denotes recurring unsuccessful implantation or early pregnancy loss associated with anomalies in parental or embryonic genetics. Chromosomal imbalance in embryos is one of the most important factors that might cause these issues. This condition is generally caused by structural problems in the parents, including balanced translocation. Carriers are often healthy, but they can have embryos with an imbalanced chromosomal composition, which might cause implantation to fail.
Aneuploidy, which means that embryos have the wrong number of chromosomes, is another big reason why they don't survive. Older mothers are more likely to have these kinds of problems because their eggs are less healthy. Moreover, single-gene mutations and DNA fragmentation in sperm may hinder embryo growth and implantation capability.

Preimplantation genetic testing (PGT), especially PGT-A (for aneuploidy) and PGT-SR (for structural rearrangements), is crucial for finding embryos that are genetically normal for transfer. In cases of repeated IVF failure, it is common to recommend karyotyping of both partners to detect any chromosomal problems that may be causing the failure.

Genetic counselling, choosing euploid embryos, and sometimes using donor gametes are also part of the management measures. Addressing genetic factors greatly increases the chances of IVF success and lowers the chance of miscarriage, leading to better reproductive outcomes for couples who are impacted.