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Burkitt lymphoma is a very aggressive kind of B-cell non-Hodgkin lymphoma that grows quickly and is commonly caused by chromosomal translocations involving the MYC gene. It mainly happens to kids, but adults can contract it too. There are three basic types of clinical forms: endemic, sporadic, and immunodeficiency-associated. The endemic kind is frequent in Africa and is closely linked to Epstein-Barr Virus (EBV) and malaria. Sporadic Burkitt lymphoma is seen all over the world, and it usually shows up as tumours in the abdomen. People with HIV/AIDS or other illnesses that weaken the immune system are more likely to suffer from Burkitt lymphoma that is linked to immunodeficiency. The symptoms vary depending on where the tumour is and can include swollen lymph nodes, lumps in the abdomen, weakness, and tiredness.

In advanced phases, the central nervous system may be affected. A biopsy and genetic tests that demonstrate MYC translocation confirm the diagnosis. Intensive multi-agent chemotherapy is the principal treatment, and it works quite well, especially in kids. Because it is so aggressive, early diagnosis and quick treatment are crucial. The prognosis is generally favourable towards therapy, contingent upon age, immunological state, and illness stage at diagnosis.